Great start to #AACR26 by

Rohit Thummalapalli· @rohit_thum · XThe author·2026-04-20 01:16· 2026-04-20Score60

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Next-generation ADCs: payload innovation

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Great start to #AACR26 by
@SawyersLabMSKCC
. NOTCH and YAP/TAZ seem to restrain NE lineage transformation and enrich for NE-low states - could TEADi promote response to DLL3 therapies in NECs?

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Conference abstracts

CT189NCT06885281matched by 代号 ZL-1310

Preliminary results from the phase 1b/2, open-label, multi-center study of ZL-1310, a DLL3-targeted ADC, in patients with neuroendocrine carcinomas and other selected solid tumors

Rohit Thummalapalli, Ming Lu, Alexander Spira, Amr Mohamed, Rahul Aggarwal, Yu Wang, Namrata Vijayvergia, Jordi Rodon, Andrew Scott Paulson, Pingkuan Zhang, Hui Yang, Yuan Xin, Jingmin Wen, Jie Chen

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Source: Rohit Thummalapalli · x.com