bioRxiv Genomics· Liao, T., Rao, C., Iyer, S., Ding, S. C., Yu, J., Lui, Z., Yang, C., Gu, W. ·· 1 day agoPickScore67
Early Prenatal Cell-Free DNA Methylation Landscape Informs Epigenetic Purification of the Circulating Fetal Genome
In brief
A first-trimester fetal cfDNA methylation reference map guides epiSIFT epigenetic enrichment, raising the median fetal cfDNA fraction from 5.1% to 28.4% in 28 prenatal plasma samples.
Why it matters
epiSIFT uses first-trimester methylation reference CpG markers to raise median fetal cfDNA fraction from 5.1% to 28.4% in 28 samples.
Source: bioRxiv Genomics · biorxiv.org