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x.com· @ · X·· 2026-04-22Score60

TROP2

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Next-generation ADCs: payload innovation

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Leif Ellison from MGH in the resistance to ADCs main session #AACR26: Deciphering escape mechanisms to TROP2-SN38 ADC SG/TRODELVY including mutations to TROP2 or TOP1, their structural basis & the potential of sequential but not concomitant combination with PARP1 inhibitors. https://t.co/THhuHKxcqP

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