mp.weixin.qq.com· 合成生物学期刊·· 6 hours agoPickScore73
Wen Liu Team Reveals TIGR04500 Family Proteins Regulate Graspetide Biosynthesis
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In brief
A team led by Wen Liu published a study in Nature Communications showing that TIGR04500 family proteins act as non-catalytic accessory proteins. They recruit ATP-grasp enzymes and recognize precursor peptides, directing the modification of ribosomally synthesized and post-translationally modified peptides.
Why it matters
A mining workflow combining structure prediction with genomic co-occurrence offers a concrete framework for locating non-catalytic accessory proteins in complex cyclic peptide biosynthesis.
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