Coming Off After Extreme Weight Loss

A poster on r/GLPGrad (u/huntybunchesofoats) detailed starting Wegovy in August 2023 at 431 lbs (~195 kg), switching to Zepbound midway after it stopped working, and losing weight down to 185 lbs (~84 kg), now hoping to stop the medication, having built habits such as a high-protein diet and macro tracking. Comments were sharply divided: u/Hot-Drop11, u/External-Cable2889 and others emphasized that the starting weight indicated "significant metabolic dysfunction," that GLP-1 drugs treat symptoms rather than root causes, that problems tend to recur after stopping, often with intense rebound hunger; u/misskinky cautioned to first clarify whether "wanting to stop" reflects one's own wishes or social bias. u/midodahwi and others offered practical advice (post-meal walks, protein first, weekly weigh-ins). On the factual level, weight regain after stopping GLP-1s (often about half) and "metabolic dysfunction not being cured" are established epidemiological and clinical observations. On the speculative level, the poster's extreme weight loss, "far beyond the scope of existing research," is a single anecdote with no generalizable significance.

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