JMC Paper Reports In Vivo Anti-GBM Activity and 76% Oral Bioavailability for GSPT1 Molecular Glue Degrader LG-NE-29

LG-NE-29 is a GSPT1 molecular glue degrader with high oral bioavailability that shows marked in vivo activity against glioblastoma. Its oral bioavailability is F = 76%, with excellent metabolic stability. The paper notes that early GSPT1 molecular glues suffered from poor pharmacokinetic properties, limited oral exposure, and weak efficacy in solid tumors.