Medicinal chemistry beyond KRAS: CDK2, WEE1, SERD
CID-078 is a cyclin A/B macrocycle; Circle Pharma reported early activity and acceptable safety at AACR.
Justin Shapiro of
@CirclePharma
with a fantastic talk about their cyclin A/B macrocyclic peptidomimetic optimization program. State-of-the-art of „small molecule“ drug discovery. As an appetizer for the 1st disclosure of cyclin A/B Ph1 inhibitor CID-078 on monday at #AACR26.
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Afshin Dowlati, Timothy A Yap, Antonio Giordano, Nehal J. Lakhani, William B McKean, Ildefonso Ismael Rodriguez Rivera, Vivek Subbiah, Kyaw Zin Thein, Judy S. Wang, Jinshu Fang, Li-Fen Liu, Peadar Cremin, Lukas Makris, Li-Pen Tsao, Lisa M. Kopp, Shivaani Kummar
Read the abstract →Source: Ingo Hartung · x.com