KRAS / RAS targeting: from platform to Phase 3
First-generation G12C drugs (sotorasib, adagrasib) bind KRAS in the off state. After treatment, RTK feedback reloads KRAS into the on state.
Congratulations to Ashenafi Bulle & colleagues on their simultaneous publication—Prolonged KRAS-MAPK Inhibition Induces Interferon Signaling that Promotes Cell State Transition & Confers Therapeutic Vulnerabilities—presented at #AACR26. Read the article: https://t.co/AToOytEDZo https://t.co/AnS2Alrpg3
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