Immunologist and Stem Cell Biologist Explain Immune Reprogramming and Metabolic Coupling in Barrier Tissues

An ImmuneZoom expert lecture, around 50 minutes long, pairs an immunologist and a stem cell biologist to discuss how immunity is reprogrammed with the microenvironment of barrier tissues. The speakers present a metabolic-coupling model in which one cell produces lactate through glycolysis and IL-17/Th17-type cells take it up as fuel, and show early-life mast cell clearance requires dendritic cells. A trial-in-a-dish approach found their inhibition regimen caused nearly 3000 differentially expressed genes versus about 127 for standard steroid or vitamin D analogue treatment.