Insightful plenary from the father of CAR-T,

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Young Kwang Chae, MD, MPH, MBA· @youngkwangchae · X·2026-04-20 02:23· 2026-04-20Score60

CLDN18

Reading

Next-generation ADCs: payload innovation

AVA6103 / pan-RAS ADC · Tricomplex pan-RAS as payload

Body

Insightful plenary from the father of CAR-T,
@carlhjune
#AACR26

CAR-T for solid tumors is finally breaking through. 7 FDA approvals in blood cancers and now solid tumors are next

Clinical signals
• CLDN18.2 (Satri-cel): 38% vs 4% ORR in gastric cancer (The Lancet 2025)

Heat 74 · 57 likes · 1 reply · 16 reposts

Conference abstracts

5640matched by 代号 ZW439

ZW439, a novel CLDN18.2-targeting pan-RAS inhibitor antibody drug conjugate for the treatment of RAS mutated pancreatic cancer

Sam Lawn, Andrea Hernández Rojas, Vidhi Khanna, Jodi Wong, Ambroise Wu, Matthew Bonderud, Victoria Harman-McKenna, Taixiang Wang, Allysha Bissessur, Kaylee Wu, Manuel Lasalle, Vincent Fung, Chayne L. Piscitelli, Dunja Urosev, Luying Yang, Graham A. Garnett, Raffaele Colombo, Jamie R. Rich, Stuart D. Barnscher

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Source: Young Kwang Chae, MD, MPH, MBA · x.com