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MeDucation· @MeDucationai · X·· 3 days agoScore45

pembrolizumab

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@DrYukselUrun asks the right next question: once perioperative EV plus pembrolizumab is standard, the real test is whether plasma and urine tumour DNA plus bladder assessment can pick out true complete responders who can keep their bladder. #ESMO26 #BladderCancer

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Conference abstracts
1239Omatched by Proffered paper: Gynaecological cancers

NRG-GY020: Phase III randomized trial of radiation +/- MK-3475 (pembrolizumab) for newly diagnosed early-stage high intermediate risk (HIR) mismatch repair deficient (dMMR) endometrioid endometrial cancer

https://esmocongress.esmo.org
2071Omatched by Proffered paper: Melanoma and other skin tumours

STARBOARD phase 3: A randomized, double-blind study of first-line (1L) encorafenib (enco), binimetinib (bini), and pembrolizumab (pembro) vs placebo (pbo) and pembro for unresectable locally advanced or metastatic BRAF V600-mutant melanoma

https://esmocongress.esmo.org
2072Omatched by Proffered paper: Melanoma and other skin tumours

Efficacy and safety of lifileucel and pembrolizumab in patients with immune check point inhibitor-naïve advanced melanoma: Final results from IOV-COM-202 study

https://esmocongress.esmo.org
2217RONCT04746300matched by Rapid oral: Genitourinary tumours, prostate, penile and testis

Updated results from the phase 1b/2 KEYNOTE-365 cohort I: Pembrolizumab (pembro) + carboplatin and etoposide chemotherapy (chemo) or chemo alone for neuroendocrine prostate cancer (NEPC)

https://esmocongress.esmo.org
2683Pmatched by NSCLC, metastatic

First-line (1L) olomorasib + pembrolizumab in KRAS G12C-mutant NSCLC: Updated results from LOXO-RAS-20001 and SUNRAY-01

https://esmocongress.esmo.org
引用@
A major step. Could combining blood and urine tumour DNA with bladder assessment help us identify who can safely avoid surgery without compromising cure? @myESMO #ESMO26 @Uromigos
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