
ESMO 2026
2026 年 10 月 23–27 日 · Madrid · 共 4876 条
sacituzumab
30 人 · 40 条
本事件热度走势
当前热度 12·可比范围峰值 12(10月27日 01:00)·近 24 小时可比范围变化 –·当前参与者 16
作为 TROP-2 靶向 ADC,萨妥珠单抗戈替康(SG)已在多项 III 期研究确立标准地位:ASCENT 研究显示在预治疗的转移性三阴性乳腺癌中,SG 使中位 PFS 达 5.6 个月,显著优于化疗的 1.7 个月[1];TROPHY-U-01 队列 1 证实其在铂类及检查点抑制剂失败的转移性尿路上皮癌中 ORR 为 27%,中位 DOR 7.2 个月[3];TROPiCS-02 进一步将在内分泌及 CDK4/6 抑制剂耐药的 HR+/HER2- 转移性乳腺癌中获益延伸至总生存获益[4];早期篮子试验亦在多种上皮癌中观察到抗肿瘤活性[6]。萨妥珠单抗替鲁替康(sac-TMT)作为新一代不可逆连接子 ADC,临床数据尚处积累期。
本届 ESMO 会上呈报了多组新数据:佛罗伦萨团队展示 SG 联合放疗治疗乳腺癌的海报数据;TROPHY-U-01 队列 7 探索 SG、恩福单抗维多汀与 zimberelimab 三联用于一线转移性尿路上皮癌(N=21),ORR 81%(含 CR 14%),中位 PFS 19.3 个月,中位 DOR 16.7 个月,中位 OS 未达中位,≥3 级治疗相关不良事件 52%,33% 患者停用 ≥1 药物;配对活检多组学分析(n=26)显示 T-DXd 后 HER2 下降 57% 但无 HER2-null,SG 后 TROP2 无一致性下调(14 例中 5 升、3 降);OptiTROP-Lung06 III 期研究在 PD-L1 阴性非鳞 NSCLC 中,sac-TMT 联合帕博利珠单抗对比化疗联合帕博利珠单抗,PFS 15.0 对 5.7 个月,≥3 级不良事件 47.6% 对 60.6%,OS 尚不成熟;另一 II 期研究在顺铂不适宜 mUC 中评估 sac-TMT 联合帕博利珠单抗(N=40),ORR 68%,DCR 88%,中位 DOR 19.4 个月,中位 PFS 11.2 个月,OS 未达中位,3-4 级 TRAE 65%(4 mg/kg)对 57%(5 mg/kg)。OptiTROP-Breast01 III 期最终 OS 分析同期发布。
主站新闻对会议数据作了补充:NEJM 以 Ahead of Print 形式刊载 OptiTROP-Lung06 全文,与会场报告的 PFS 与安全性数字一致;BioSpace 报道默沙东高管指出 sac-TMT 采用不可逆连接子,血液稳定性处于“恰到好处”区间,区别于 Trodelvy 与 Datroway 的可逆连接子,旨在平衡载荷过早释放导致的骨髓抑制与释放过慢影响疗效;另有中文产业新闻披露科伦博泰自研 TROP2 ADC 芦康沙妥珠单抗(SKB264)在 2L+ TNBC III 期最终 OS 分析中位 OS 14.7 个月对比化疗 9.9 个月,HR=0.60,调整后 HR=0.55,属于不同分子实体。
这些数据共同推进了 TROP2 ADC 从单药向联合、从二线向一线、从单靶点向双 ADC 联合的演进:三联方案在尿路上皮癌展示出高缓解率与持久 PFS,但 ≥3 级毒性近六成、三分之一患者需减药或停药,提示递送耐受性是关键瓶颈;sac-TMT 在 PD-L1 阴性 NSCLC 与顺铂不适宜 mUC 中均显示出优于化疗或单药 ADC 的活性,且跨生物标志物亚组一致,支持其作为化疗替代者的潜力;耐药机制研究揭示靶点非依赖性逃逸普遍存在。局限在于:三联队列样本量极小(N=21/18),随访较短;OptiTROP-Lung06 与 sac-TMT mUC 研究 OS 均未成熟;耐药队列仅 26 例且异质性大;毒性管理策略(如 G-CSF 预防性使用)尚未标准化。
- 1.Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer · N Engl J Med 2021
- 2.Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer · N Engl J Med 2019
- 3.TROPHY-U-01: A Phase II Open-Label Study of Sacituzumab Govitecan in Patients With Metastatic Urothelial Carcinoma Progressing After Platinum-Based Chemotherapy and Checkpoint Inhibitors · J Clin Oncol 2021
- 4.Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial · Lancet 2023
- 5.Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) · Oncotarget 2015
- 6.Sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, for patients with epithelial cancer: final safety and efficacy results from the phase I/II IMMU-132-01 basket trial · Ann Oncol 2021
Daniel Castellano@cdanicas OncoAlert@OncoAlert NEJM@NEJM Icro Meattini@Icro_Meattini Julian Chavarriaga@chavarriagaj Dra. María Natalia Gandur Quiroga@nataliagandur 引用@🧬 Can triplet combinations improve outcomes in advanced urothelial cancer? And how do we manage their toxicity? #OAOnTheGo Series In this new OncoAlert video live from the floor at #ESMO26, Dr. Sara Coca Membribes, @scocmem medical oncologist and genitourinary (GU) clinical research fellow at the Barts Cancer Institute🇬🇧 , discusses the results of TROPHY Cohort 7, evaluating sacituzumab govitecan (SG), enfortumab vedotin (EV), and a PD-1 inhibitor. 🔬 Key takeaways: ▪️ All 18 patients achieved tumor shrinkage, with durable responses. ▪️ No treatment-related deaths were reported. ▪️ Approximately 60% of patients experienced Grade 3 adverse events. ▪️ G-CSF support was mandatory in the study. With several trials exploring frontline triplet combinations using different ADCs, payloads, and targeted therapies—including FGFR3 inhibition in the FORAGER trial—the challenge is not only achieving efficacy, but also managing toxicity without compromising treatment outcomes. 🎥 Watch Dr. Sara Coca Membribes' video for her insights into these promising strategies and why toxicity management is essential for the future of combination therapy. #UrothelialCancer #BladderCancer Pinging Our Faculty @DrChoueiri, @tompowles1, @apolo_andrea, @neerajaiims, @montypal, @Silke_Gillessen, @AOmlin, @brian_rini, @PGrivasMDPhD, @TiansterZhang, @amerseburger, @DrDanielHeng, @HHammersMD, @scocmem, @AndreaNecchi, @AmandaNizamMD, @drenriquegrande, @nataliagandur, @AlbigesL, @cdanicas, @declangmurphy, @seanmmcbride, @shilpaonc, @DrRanaMcKay, @scserendipity1, @DrYukselUrun, @ravikanesvaran, @BraunMDPhD, @EfstathiouEleni, @mzugman, @crisbergerot, @niklas_kluemper @Markuseckstein3
Elisabetta Bonzano MD, PhD@to_be_elizabeth 引用@🧬 Can triplet combinations improve outcomes in advanced urothelial cancer? And how do we manage their toxicity? #OAOnTheGo Series In this new OncoAlert video live from the floor at #ESMO26, Dr. Sara Coca Membribes, @scocmem medical oncologist and genitourinary (GU) clinical research fellow at the Barts Cancer Institute🇬🇧 , discusses the results of TROPHY Cohort 7, evaluating sacituzumab govitecan (SG), enfortumab vedotin (EV), and a PD-1 inhibitor. 🔬 Key takeaways: ▪️ All 18 patients achieved tumor shrinkage, with durable responses. ▪️ No treatment-related deaths were reported. ▪️ Approximately 60% of patients experienced Grade 3 adverse events. ▪️ G-CSF support was mandatory in the study. With several trials exploring frontline triplet combinations using different ADCs, payloads, and targeted therapies—including FGFR3 inhibition in the FORAGER trial—the challenge is not only achieving efficacy, but also managing toxicity without compromising treatment outcomes. 🎥 Watch Dr. Sara Coca Membribes' video for her insights into these promising strategies and why toxicity management is essential for the future of combination therapy. #UrothelialCancer #BladderCancer Pinging Our Faculty @DrChoueiri, @tompowles1, @apolo_andrea, @neerajaiims, @montypal, @Silke_Gillessen, @AOmlin, @brian_rini, @PGrivasMDPhD, @TiansterZhang, @amerseburger, @DrDanielHeng, @HHammersMD, @scocmem, @AndreaNecchi, @AmandaNizamMD, @drenriquegrande, @nataliagandur, @AlbigesL, @cdanicas, @declangmurphy, @seanmmcbride, @shilpaonc, @DrRanaMcKay, @scserendipity1, @DrYukselUrun, @ravikanesvaran, @BraunMDPhD, @EfstathiouEleni, @mzugman, @crisbergerot, @niklas_kluemper @Markuseckstein3
Annals of Oncology@Annals_Oncology Uğur Özkerim@UOzkerim Julian Chavarriaga@chavarriagaj David H Aggen, MD PhD@Dr_Aggen OncLive.com@OncLive Nieves Martinez Lago MD PhD@DraMartinezLago Elisabetta Bonzano MD, PhD@to_be_elizabeth ScienceLink@sciencelinkonco Rami Manochakian MD, FASCO@RManochakian Alfredo Addeo MD@Alfdoc2 Martin ZapataLaguado@zapatalaguadomd Nirmal Raut@oncologician Martin ZapataLaguado@zapatalaguadomd Grupo GETNE@GrupoGetne 引用@🇪🇸 #ESMO26 🧬 SETHY | Phase II – Spanish GETNE study 💊 Sacituzumab govitecan (TROP2 ADC) 🔬 DTC (n=24): 🎯 ORR 4.4% | mPFS 5.5 mo 🔬 ATC (n=13): 🎯 ORR 16.7% | mPFS 2.9 mo 💡 Preliminary activity in ATC. TROP2 biomarker analysis awaited! 👏 Great work by @GrupoGetne @OncoAlert
ScienceLink@sciencelinkonco MedShr@medshronline Yakup Ergün@dr_yakupergun がんナビ通信@cancer_navi ScienceLink@sciencelinkonco ilyas sahin, MD@ilyassahinMD Abdullah Mohammed@AMohammedAM1 MBC Advocate@MBCadvocate OncoAlert@OncoAlert