Cynthia Kenyon Explains How daf-2 Mutations Double C. elegans Lifespan
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In an iBiology Science Stories talk on YouTube, Cynthia Kenyon explains her landmark finding that mutations in daf-2, the insulin/IGF-1 receptor, double the lifespan of C. elegans. Reduced insulin/IGF-1 signaling allows the DAF-16/FOXO transcription factor to enter the nucleus and boost stress-response and antioxidant genes, slowing aging. The discovery established that aging is a genetically regulated program rather than simple random wear, and it underpinned later research on senescent cells and senolytic therapies. The talk is available for viewing, and no follow-up developments have been reported.
Written by a model from the reports · updated 2 hours ago
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- youtube.comCynthia Kenyon Explains How daf-2 and Insulin/IGF-1 Signaling Double C. elegans Lifespan
In an iBiology Science Stories talk on YouTube, Cynthia Kenyon describes how mutations in daf-2, the insulin/IGF-1 receptor, double the lifespan of C. elegans. Reduced insulin/IGF-1 signaling lets DAF-16/FOXO enter the nucleus and turn up stress-response and antioxidant genes, slowing aging. The work established that aging is a genetically regulated program rather than random wear, underpinning later research on senescent cells and senolytics.
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