Disrupting nuclear damage rescues heart function and survival in mice with LMNA cardiomyopathy
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A Cornell team publishing in Circulation Research used the DN KASH protein to disrupt the LINC complex in mice with LMNA dilated cardiomyopathy, a disease in which mechanical stress damages the nuclei of heart muscle cells. The intervention cut nuclear damage in those cells by more than half. Cardiac function returned close to normal, and survival extended from weeks to over a year. The approach targets a root mechanism of the disease rather than its symptoms. Still open is whether the strategy can be translated to patients with LMNA dilated cardiomyopathy, and no clinical work has yet been reported.
Written by a model from the reports · updated 3 hours ago
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- medicalxpress.comPickReducing nuclear damage improves heart function and survival in mice
A Cornell team publishing in Circulation Research used the DN KASH protein to disrupt the LINC complex, cutting nuclear damage in heart muscle cells of mice with LMNA dilated cardiomyopathy by more than half. Cardiac function returned close to normal, and survival extended from several weeks to over a year.
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