Dietary serine and glycine restriction delays cancer-associated cachexia in mice

A preprint posted on bioRxiv reports that restricting the amino acids serine and glycine in the diet delays the onset of cancer-associated cachexia in tumour-bearing mice. The effect works through the host rather than the tumour: the diet did not act by slowing tumour growth, but by preserving adipose tissue depots. Mechanistically, the restricted diet remodeled systemic metabolism, reducing oxidative lipid stress and attenuating inflammatory responses. The findings position serine and glycine availability as a regulator of host metabolic resilience during cancer progression, and suggest a possible dietary angle on cachexia, a wasting syndrome that remains a major problem in advanced cancer. The work is at the preprint stage in mice, with no human data yet.

Written by a model from the reports · updated 3 hours ago