Yogurt strain research at Danisco revealed CRISPR as a bacterial immune system
Start here
Working on phage resistance in yogurt and cheese cultures at the Danish food ingredients company Danisco, Rodolphe Barrangou's team showed that CRISPR functions as a bacterial adaptive immune system. Archived frozen strains that had become phage-resistant differed from their parents only by an added repeat and spacer in the CRISPR array. Adding a spacer conferred resistance, while removing it or knocking out CAS9 abolished it, tying the mechanism directly to acquired immunity. The team published its first high-impact CRISPR paper in March 2007, establishing the biological role of what became a genome-editing tool.
Written by a model from the reports · updated 2 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- youtube.comPickDanisco yogurt strain research showed CRISPR is a bacterial adaptive immune system
Rodolphe Barrangou of Danisco, a Danish food ingredients maker and leading producer of yogurt and cheese cultures, traced how industrial phage resistance work revealed CRISPR function. Archived frozen strains differed from their parents only by an added repeat and spacer in the CRISPR array, and adding a spacer conferred resistance while removing it or knocking out CAS9 abolished it. The team published its first high-impact CRISPR paper in March 2007, proving CRISPR is a bacterial adaptive immune system.
Heat trend for this story
Heat now 9·Peak in the comparable set 10 (Oct 18 04:00)·Change over 24h in the comparable set –
The trend compares only the participants observed in full throughout, so its set can be smaller than the heat figure itself. Move the pointer or click the chart for an hour's heat; the left and right arrow keys work too.