Expert lecture maps DNA methylation programs driving CD8 T cell exhaustion
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A 53-minute ImmuneZoom expert lecture explains how functional and exhausted CD8 T cells acquire distinct DNA methylation programs. Chronic antigen exposure, in tumors and in chronic viral infection, imprints an exhausted epigenetic state that gradually erodes responses to checkpoint blockade and CAR-T therapy. The lecture distinguishes exhaustion acquired after treatment from exhaustion that pre-exists in CAR-T and TIL products before therapy, implying different windows for intervention. Targeted epigenetic reprogramming is raised as a possible way to restore T cell persistence. Open questions are whether such reprogramming works and is safe in patients.
Written by a model from the reports · updated 2 hours ago
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- youtube.comExpert lecture maps DNA methylation programs that drive CD8 T cell exhaustion and limit immunotherapy
An ImmuneZoom expert lecture on YouTube, 53 minutes long, explains how functional and exhausted CD8 T cells acquire distinct DNA methylation programs, with chronic antigen exposure in tumors and chronic viral infection imprinting an exhausted epigenetic state that erodes responses to checkpoint blockade and CAR-T over time. It distinguishes post-treatment acquired exhaustion from pre-existing exhaustion in CAR-T and TIL products before therapy, implying different intervention windows. Targeted epigenetic reprogramming may restore T cell persistence, but clinical efficacy and safety remain to be validated.
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