Shane Crotty reviews how vaccine types shape immune memory durability
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In a Cell Press expert lecture published on YouTube, immunologist Shane Crotty reviewed how different vaccine platforms induce and maintain immune memory. He presented evidence of remarkable durability from some vaccines: smallpox vaccine memory B cells persist for over 60 years, with antibodies still detectable 88 years after vaccination, and yellow fever live vaccine CD8 T cells divide roughly every 1.5 years, as shown by deuterium labelling. By contrast, inactivated coronavirus vaccines generate B cell memory 10 to 100 times lower than mRNA vaccines or natural infection. Crotty identified open questions in the field, including the lack of direct quantification methods for antigen-binding memory cells and insufficient longitudinal data to compare durability across vaccine types.
Written by a model from the reports · updated 2 hours ago
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- youtube.comShane Crotty reviews durability and mechanisms of immune memory across vaccine types
Shane Crotty delivered an expert lecture, published by Cell Press on YouTube, reviewing how different vaccines induce and maintain immune memory. He cited smallpox vaccine memory B cells persisting over 60 years with antibodies detectable 88 years after vaccination, yellow fever live vaccine CD8 T cell data showing division roughly every 1.5 years by deuterium labelling, and inactivated coronavirus vaccines producing B cell memory 10 to 100 times lower than mRNA vaccines or infection. He noted gaps including lack of direct quantification of antigen-binding memory cells and insufficient longitudinal data.
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