The pan-cancer whole-genome landscape of Adolescent and Young Adult solid cancers
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Whole-genome sequencing of paired tumor-normal samples from 698 adolescents and young adults (AYAs, 18-39 years) and 5,220 older adults shows AYA tumors carry fewer somatic variants but largely the same genetic drivers. Pathogenic germline variants concordant with tumor type were enriched in AYAs (10.9% versus 6.6% in matched older adults, p=0.006), often with a somatic second hit, supporting comprehensive tumor-normal profiling beyond driver-focused testing.
Excerpted from biorxiv.org
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- biorxiv.orgThe pan-cancer whole-genome landscape of Adolescent and Young Adult solid cancers
Whole-genome sequencing of paired tumor-normal samples from 698 adolescents and young adults (AYAs, 18-39 years) and 5,220 older adults shows AYA tumors carry fewer somatic variants but largely the same genetic drivers. Pathogenic germline variants concordant with tumor type were enriched in AYAs (10.9% versus 6.6% in matched older adults, p=0.006), often with a somatic second hit, supporting comprehensive tumor-normal profiling beyond driver-focused testing.
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