NEJM expert review: statins in the elderly, obexelimab, giredestrant and weekly oral HIV regimen
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A NEJM Group expert review examines four notable studies. In 9,971 Australians aged 70 or older without cardiovascular disease, diabetes or dementia, randomized to atorvastatin 40 mg daily or placebo, starting statins proved beneficial and safe. A phase III trial found obexelimab lowered relapse risk and corticosteroid exposure in IgG4-related disease at 52 weeks. In ER-positive, HER2-negative advanced breast cancer, giredestrant plus everolimus improved outcomes after progression on CDK4/6 inhibitors. And a weekly oral regimen of islatravir plus lenacapavir maintained viral suppression in patients switching from daily B/F/TAF. Separately, Europe has begun its first Joint Clinical Assessment under the HTA regulation, placing comparative effectiveness at the centre of drug evaluation.
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- youtube.comNEJM expert review covers statins in the elderly, IgG4-related disease, ER+ breast cancer and weekly oral HIV regimen
NEJM Group's expert review highlights four studies: 9,971 Australians aged 70 or older without cardiovascular disease, diabetes or dementia randomized to atorvastatin 40 mg daily or placebo found starting statins beneficial and safe; phase III obexelimab lowered relapse risk and corticosteroid exposure in IgG4-related disease at 52 weeks; giredestrant plus everolimus improved outcomes after CDK4/6 inhibitor progression in ER+/HER2- advanced breast cancer; and weekly oral islatravir plus lenacapavir maintained viral suppression after switching from daily B/F/TAF. Europe's first Joint Clinical Assessment under the HTA regulation places comparative effectiveness at the centre of drug evaluation.
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