Ageing muscle stem cells lose repair capacity through epigenetic shifts, researcher explains
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In a Cold Spring Harbor Laboratory interview for its Leading Strand channel, researcher Sartorelli described how ageing impairs muscle stem cells, the satellite cells that maintain muscle homeostasis and repair damage throughout life. She attributes their declining repair capacity to both cell-intrinsic mechanisms and external microenvironmental factors, pointing to global increases in the repressive H3K27 trimethylation mark and NF-κB demethylation that drives an inflammation programme. She also presented intervention possibilities: supplementing α-ketoglutarate and glutamine improved proliferation and muscle repair in aged stem cells, and tools such as dCas9 can recruit demethylases or methyltransferases to tune epigenetic marks at specific loci. The account comes from a single interview, so experimental details, effect sizes and clinical applicability are not yet documented here.
Written by a model from the reports · updated 2 hours ago
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- youtube.comSartorelli explains metabolic and epigenetic control of muscle stem cell ageing in CSHL interview
In a Cold Spring Harbor Laboratory interview series for its Leading Strand channel, researcher Sartorelli explains how ageing impairs muscle stem cells, or satellite cells, which maintain muscle homeostasis and repair damage throughout life. She attributes their declining repair capacity to both cell-intrinsic mechanisms and external microenvironmental factors, including global rises in the repressive H3K27 trimethylation mark and NF-κB demethylation that drives an inflammation programme. Supplementing α-ketoglutarate and glutamine improved proliferation and muscle repair in aged stem cells, and tools such as dCas9 can recruit demethylases or methyltransferases to tune epigenetic marks at specific loci.
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