FGFBP1 Cells Identified as LGR5-Independent Source of Intestinal Regeneration
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Kelley Yan's team discovered a proliferative cell population marked by FGFBP1 that regenerates intestinal stem cells independently of LGR5. Blocking R-spondin completely eliminated LGR5-positive cells in the intestinal epithelium, yet the epithelium continued to regenerate, pointing to an alternative regenerative source. Single-cell RNA sequencing in R-spondin-inhibited models identified FGFBP1-positive cells sitting upstream of LGR5 CBC cells, regenerating them every 1-2 weeks from the upper crypt. The finding challenges the view that LGR5-positive cells are the sole engine of intestinal renewal. The group is now testing whether FGFBP1-positive cells also maintain homeostasis and regeneration in the stomach and other glandular epithelia, which remains the open question.
Written by a model from the reports · updated 2 hours ago
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- youtube.comKelley Yan Identifies FGFBP1 Cells That Regenerate Intestinal Stem Cells Independently of LGR5
Kelley Yan's team found that blocking R-spondin completely eliminates LGR5-positive cells in the intestinal epithelium, yet the epithelium keeps regenerating, pointing to an LGR5-independent regenerative source. Single-cell RNA sequencing in R-spondin-inhibited models identified a proliferative population marked by FGFBP1 that sits upstream of LGR5 CBC cells and periodically regenerates them every 1-2 weeks from the upper crypt. The group is now testing whether FGFBP1-positive cells also maintain homeostasis and regeneration in the stomach and other glandular epithelia.
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