Ali Shilatifard Ties Transcription Elongation Control to Disease and Aging in CSHL Lecture
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Ali Shilatifard delivered a Cold Spring Harbor Laboratory Leading Strand lecture arguing that transcription elongation control is a central regulator of gene expression. Drawing on 30 years of work from his laboratory, he linked single-point mutations in the super elongation complex to neurodevelopmental disorders such as Coffin-Lowry syndrome, and noted that elongation factors are also implicated in cancer. In a session on aging, he explored whether elongation factors can be targeted inside cells to counter senescence-related phenotypes. The lecture frames elongation regulation as a unifying mechanism spanning development, cancer and aging, and raises the open question of whether such factors can be therapeutically modulated. Whether intracellular targeting of elongation factors can effectively counter age-related phenotypes remains unresolved.
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Ali Shilatifard discussed transcription elongation regulation at a CSHL Leading Strand lecture, arguing on the basis of 30 years of his laboratory's work that elongation control is central to gene expression and that its disruption can cause disease. He connected single-point mutations in the super elongation complex to neurodevelopmental disorders such as Coffin-Lowry syndrome, and noted elongation factors are also linked to cancer. In a session on aging, he discussed whether elongation factors can be targeted inside cells to counter senescence-related phenotypes.
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