EBV infection implicated in multiple sclerosis through cross-reactive antibodies and B cell dysfunction
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Epstein-Barr virus infection is increasingly viewed as a driver of multiple sclerosis. A 2022 study identified clonally expanded B cells in MS patients that recognize both the EBV protein EBNA1 and the central nervous system protein gliaCAM, supporting molecular mimicry as a disease mechanism. An expert talk on ImmuneZoom, running 46 minutes, further discusses how EBV latency patterns in infected B cells and two pathogenic routes may lead to autoimmunity. Clinical evidence is consistent with B cells as central players: anti-CD20 antibodies that deplete B cells have proven effective in large MS trials. Open questions include how latency patterns translate into pathogenic routes in patients and how these mechanisms can be targeted beyond B cell depletion.
Written by a model from the reports · updated 2 hours ago
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- youtube.comEBV infection may drive multiple sclerosis through cross-reactive antibodies and B cell dysfunction
A 2022 study found clonally expanded B cells in MS patients that recognize both the EBV protein EBNA1 and the CNS protein gliaCAM, pointing to molecular mimicry as a mechanism. An expert talk on ImmuneZoom also discusses how EBV latency patterns in infected B cells and two pathogenic routes may lead to autoimmunity, and how anti-CD20 antibodies depleting B cells have proven effective in large MS trials. The talk runs 46 minutes.
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