STING Activation Triggers IL-35-Producing Regulatory B Cells That Suppress NK Antitumor Immunity
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A mechanism presented in an expert talk on ImmuneZoom describes how activation of the STING pathway induces regulatory B cells that produce IL-35. These IL-35-producing Breg cells inhibit NK cell cytotoxicity and cytokine production, weakening innate immune clearance of tumors. The speaker proposes "unionized STING," an mRNA/LNP-delivered STING agonist, as a tool for tuning nucleic acid sensing. The talk also outlines a therapeutic angle: blocking IL-35 signaling or depleting this Breg subset may release suppressed NK cell function and strengthen antitumor immunity. The work is currently at the level of mechanism and proposed strategy, with the ideas awaiting further validation.
Written by a model from the reports · updated 2 hours ago
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- youtube.comSTING Activation Induces IL-35-Producing Regulatory B Cells That Suppress NK Antitumor Immunity
An expert talk on ImmuneZoom lays out a mechanism in which activation of the STING pathway induces regulatory B cells producing IL-35, which then inhibit NK cell cytotoxicity and cytokine production, weakening innate immune clearance of tumors. The speaker proposes "unionized STING," an mRNA/LNP-delivered STING agonist, as a tool for tuning nucleic acid sensing. Blocking IL-35 signaling or this Breg subset may release suppressed NK function and strengthen antitumor immunity.
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