Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury.

Starting renal-replacement therapy with intermittent hemodialysis rather than continuous renal-replacement therapy was not noninferior in critically ill adults with acute kidney injury. The trial stopped early after 554 patients were randomized because of higher mortality with intermittent hemodialysis: day-90 death occurred in 63.1% versus 53.5%, and major adverse kidney events in 78.1% versus 71.6%. Clinicians choosing an initial modality now have mortality evidence favoring continuous therapy.