Wendy Garrett of Harvard Discusses Microbial Metabolites, Gut Immunity and Colorectal Cancer

Wendy Garrett of Harvard Chan and Dana-Farber gave a 50-minute GLOBAL IMMUNOTALKS lecture on how host-microbiome interactions shape intestinal immunity in colorectal cancer, IBD and chronic kidney disease. She described how short-chain fatty acids signal through free fatty acid receptors to support FoxP3+ regulatory T cells and ILC3s, how Fusobacterium nucleatum adheres to adenomas and cancers and suppresses immune-mediated killing via type 3 inflammation and IL-17, and how single-cell RNA-seq reveals epithelial stem niches and eosinophil roles.