Meta-analysis of 2017-2025 trials ranks CPAP and exercise best for lowering apnea-hypopnea index

A MedCram expert review examines a meta-analysis of dozens of randomized controlled trials published between 2017 and 2025 comparing treatments for obstructive sleep apnea (OSA). CPAP and physical activity were most effective at reducing the apnea-hypopnea index, with mandibular advancement devices and hypoglossal nerve stimulation next, while CPAP combined with lifestyle changes or a GLP-1 performed better still. Stimulants such as modafinil, hypoglossal nerve stimulation, CPAP and physical activity improved daytime sleepiness on the Epworth scale, with physical activity ranking highest for quality of life.