Science Advances·· 11 hours agoPickScore59
Long-term immunoprophylaxis by TLR9 ligand mediates macrophage-ILC cross-talk against respiratory viral infection.
In brief
The study found that a single intranasal dose of K3-SPG, a TLR9 ligand CpG oligodeoxynucleotide-schizophyllan complex, protected hosts against lethal respiratory virus infection for 100 days, independent of antigen-specific immunity.
Why it matters
Single-dose protection for about 100 days in a lethal mouse model, with mechanisms tied to biphasic innate activation of macrophages and ILCs, offers a reference for bridging vaccine gaps.
Source: Science Advances