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Mitochondrial ATP promotes CD8+ T cell effector differentiation via phosphocreatine and BAF chromatin remodeling
In brief
Craig B. Thompson's team at Memorial Sloan Kettering Cancer Center reports in Cell that D-alpha-hydroxybutyrate (DAHB) increases mitochondrial ATP production by about 82% through fatty acid oxidation and distributes high-energy phosphate to the perinuclear region via the phosphocreatine-creatine kinase system. This supports BAF/mSWI-SNF-dependent chromatin remodeling, keeping effector gene loci such as Prf1, Ifng and Tnf open and thereby enhancing CD8+ T cell effector differentiation.
Why it matters
It links mitochondrial ATP to nuclear BAF chromatin remodeling through the phosphocreatine-creatine kinase system, suggesting metabolic targets to strengthen T cell antitumor effects.
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