Cell·· 15 hours agoPickScore73
CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer.
In brief
Single-cell CRISPR screens identified Dusp5 and Zfp219 as drivers of CD8+ T cell dysfunction in aged tumors. Deleting Zfp219 caused epigenetic reprogramming, raised cytotoxic molecule expression, and combined with immune checkpoint inhibitors to clear tumors in aged mice; human ZNF219 levels in intratumoral CD8+ T cells correlated with worse survival after immunotherapy in older patients. The work names two targetable genes for rejuvenating antitumor immunity in aging.
Why it matters
It pinpoints gene targets that restore T cell function and checkpoint inhibitor response in aged tumors, with a human survival correlate.
Source: Cell · doi.org