biorxiv.org· Zhang, A., Fang, Y., Peng, R., Yan, M., Chen, Z., Li, T., Tan, J., Sun, L., Chen, Z. ·· 18 hours agoScore54
Combining an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA lipid nanoparticles promotes systemic tumor control
Combining an autoactivated cGAS mutant with membrane-tethered IL-12 via mRNA lipid nanoparticles promotes systemic tumor control
In brief
An mRNA lipid nanoparticle platform co-delivering an autoactivated cGAS mutant (cGASR241E) and membrane-tethered IL-12 (IL-12TM) induced systemic antitumor immunity in mice. cGASR241E LNPs activated host STING signaling in vivo, while IL-12TM LNPs reduced regulatory T cells and restored effector function in tumor-infiltrating T cells, suppressing distal tumors across multiple mouse models. The combination also enhanced responsiveness to PD-L1 blockade; efficacy required CD8+ T cells and IFNg signaling.
Source: biorxiv.org · biorxiv.org