Fluid Therapy in Mechanically Ventilated Critically Ill Adult Patients.

In 206 ICUs across 41 countries, fluid therapy for mechanically ventilated adults was driven mainly by maintenance and replacement fluids (31.9%) and creep fluids (30.9%), not resuscitation (16.0%). Among 2454 patients, median daily fluid input peaked at 3.0 L on day 1 after intubation, with balance near-neutral by day 3. Isotonic balanced crystalloids (48.9%) and saline (27.0%) dominated, and substantial between-site variation persisted after case-mix adjustment.