A relational architecture of the human genome

Systematic in silico perturbation of every position of the complete telomere-to-telomere human genome, using Nucleotide Transformer v3 on an exascale compute cluster, produced nucleotide-resolution dependency maps organized as a directed, weighted network of position-to-position genomic relationships. The network recovers known biological features and reveals recurrent directional architectures the authors term 'relons', spanning coding, non-coding and unannotated regions. Relons reflect evolutionary and functional constraints and associate with human genetic variation and pathogenic variants, adding a higher-order relational layer to genome organization beyond linear and 3D structure.