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Liu Wen team reveals chaperone-like protein mechanism guiding ribosomal peptide biosynthesis in Nature Communications
In brief
Wen Liu's team at Shanghai Jiao Tong University reports in Nature Communications that TIGR04500 family proteins use a molecular chaperone-like mechanism to assist ATP-grasp enzymes in catalyzing the biosynthesis of ribosomal peptides (RiPPs). AlphaFold3-assisted genome mining identified 285 related protein sequences.
Why it matters
The study reclassifies TIGR04500 proteins from unknown function to RiPPs biosynthesis cofactors, informing genome mining and enzyme engineering.
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