WeChat· iNature·· 1 day agoPickScore81
Science: Small intestinal epithelium sets differentiation by Hes1 oscillation frequency
In brief
On October 15, 2026, Katharina F. Sonnen's team at Utrecht University published a study in Science showing that intestinal epithelium determines cell differentiation direction through Hes1 oscillation frequency rather than average Notch levels.
Why it matters
Shifts the view of Notch-controlled intestinal differentiation from total levels to oscillation frequency, offering an experimentally testable coding framework.
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