Near-complete killifish genome assembly enables locus-level transposable element profiling
Start here
Researchers have produced an improved chromosome-scale genome assembly of the African turquoise killifish, Nothobranchius furzeri, a key model for aging research. The assembly resolves tandem repeats occupying up to 28.0% of the whole genome and matches experimentally estimated genome size and chromosome number. Using this assembly alongside other complete vertebrate assemblies, the team demonstrates that choices in tandem repeat detection methods substantially reshape the apparent transposable element landscape: different TE workflows recover complementary sets of age- and sex-associated TE loci in a sex-balanced multi-tissue aging cohort. Combinatorial use of repeat detection programs supports robust, locus-level profiling of transposable elements. The work is currently a preprint. Open questions include how the complementary TE loci identified by different workflows relate to biological aging processes.
Written by a model from the reports · updated 2 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- biorxiv.orgNear-complete genome assembly of the African turquoise killifish enables locus-level profiling of transposable element expression
An improved chromosome-scale assembly of the African turquoise killifish, Nothobranchius furzeri, resolves tandem repeats occupying up to 28.0% of the whole genome and matches the experimentally estimated genome size and chromosome number. Using this and other complete vertebrate assemblies, the authors show that choices in tandem repeat detection reshape the apparent transposable element landscape, with different TE workflows recovering complementary sets of age- and sex-associated TE loci in a sex-balanced multi-tissue aging cohort. Combinatorial use of repeat detection programs supports robust, locus-level profiling of TEs.
Heat trend for this story
Not enough continuous observation yet to draw a trend.