biorxiv.org· Grabinski, N. S., Reardon, J. J., Shah, S., Adorno, J. J., Lee, P., Packard, R. L., Ramamoorthy, Y., Thies, K. A., Chakravarthy, P. A., Agarwal, S. S., Spehar, J. M., Arsiwala, T. A., Carpenter, J. W., Mossing, A. A., Schiebel, J. G., Steck, S. A., Didier, A. J., Richardson, D. S., Kollin, L., Venere, M., Godbout, J. P., Lockman, P. R., Beyer, S., Corps, K. N., Winter, J. O., Song, J. W., Sizemore, S. T., Sizemore, G. M. ·2026-10-16 08:00· 21 hours agoScore48

Breast Cancer-derived PDGFB Remodels the CNS Vascular Niche to Promote Brain, Spinal and Leptomeningeal Metastasis

In brief

Breast cancer-derived PDGFB remodels the CNS vascular niche to promote metastasis to the brain, spinal cord and leptomeninges. In triple-negative breast cancer models, PDGFB enhanced human brain microvascular endothelial cell sprouting, increased permeability in 3D blood-brain barrier models and disrupted tight junction proteins, with permeability changes seen in both PDGFR-beta-positive and PDGFR-beta-negative endothelial systems. In vivo, PDGFB raised CNS metastatic burden and drove spinal and leptomeningeal colonization, and patient transcriptomic datasets showed angiogenesis pathway enrichment in PDGFB-high tumors from patients with CNS metastases.

Source: biorxiv.org · biorxiv.org

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