biorxiv.org· Papalazarou, V., Coomes, J., Rossi, L., Lionello, V. M., Furlani, I., Tedesco, F. S., Vousden, K. ·· 22 hours agoScore48
NAD+ limitation and α-ketoglutarate depletion define cancer induced muscle atrophy
NAD+ limitation and α-ketoglutarate depletion define cancer induced muscle atrophy
In brief
Pancreatic cancer cells secrete lactate that lowers the NAD+/NADH ratio in myotubes, impairing oxidative metabolism and depleting alpha-ketoglutarate (KG), which drives muscle atrophy involving cytoskeletal stress and increased myosin contractility. Restoring NAD+ or KG levels rescued myotube atrophy, and skeletal muscle from cachexia mouse models showed reduced KG levels, defining a targetable tumour-muscle crosstalk mechanism.
Source: biorxiv.org · biorxiv.org