medicalxpress.com· Medical Xpress - Cancer·· 23 hours agoPickScore71
The hidden role of a cancer treatment target could explain toxic side effects
The hidden role of a cancer treatment target could explain toxic side effects
In brief
Research from the MRC Laboratory of Medical Sciences, the University of Oxford and UCL has found that Wee1 deactivates a protein degradation complex early in the cell cycle of healthy cells, which may explain the toxic side effects of Wee1 inhibitors.
Why it matters
Model predictions and cell experiments point to Wee1's early function, supporting work on inhibitor toxicity and tumor sensitivity.
Source: medicalxpress.com · medicalxpress.com