Cell·· 9 hours agoPickScore75
Functional diversification of the cephalopod proteome by RNA editing.
Functional diversification of the cephalopod proteome by RNA editing.
In brief
Proteome-scale analysis of the squid Doryteuthis pealeii confirms translation of 7,997 RNA-recoded sites and shows how recoding alters protein stability, localization, post-translational modifications and enzymatic activity. Recoding of the E3 ligase MARCHF5 shifts substrate ubiquitylation and perturbs mitochondrial homeostasis, linking cephalopod RNA editing to organelle function.
Why it matters
Provides direct protein-level evidence for how extensive squid RNA recoding diversifies protein function and cellular physiology.
Source: Cell · doi.org