Macropinocytosis-mediated recyclable LYTACs (McR-TACs) for receptor-independent protein degradation

The paper introduces macropinocytosis-mediated recyclable LYTACs (McR-TACs), a receptor-independent approach to degrading extracellular and membrane proteins. The design is meant to exploit macropinocytosis so that the degrader is recycled and can act on its target across multiple cycles, addressing the reliance of conventional lysosome-targeting chimeras on specific cell-surface receptors. The title positions the work within the extracellular targeted protein degradation field.