#其他

#其他

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Oct 8Thu

Thursday

21:50
CellPickScore8484
A non-canonical function of glutathione to suppress ferroptosis via FSP1.
Glutathione suppresses ferroptosis independently of GPX4, protecting GPX4 knockout cells through a pathway pinpointed by genome-wide CRISPR-Cas9 screening: ferroptosis suppressor protein 1 (FSP1). FSP1 uses GSH to generate reduced ubiquinone, which scavenges oxidized lipids, and inhibition of FSP1 abolishes this protection in vitro and in vivo. The pathway differs from NAD(P)H-driven ubiquinone reduction by not requiring FAD.
Research #Primary research #Other
Why it matters: It uncovers a GPX4-independent route by which glutathione restrains ferroptosis, relevant to ferroptosis-related disease therapy.

Sep 11Fri

Friday

19:45
NaturePickScore5454
The past and future impact of climate change on childhood malaria in Africa.
Human-caused climate change has had a small net effect on childhood malaria across sub-Saharan Africa: rising temperatures probably increased cases in East and southern Africa but averted a comparable number in West Africa, a net impact of 1 excess case per 1,000 children (95% CI -4 to 6). Projections to 2100 suggest climate change could avert 1 to 20 cases per 1,000 children continent-wide, but limiting warming from 3 °C to under 2 °C could prevent an average of 5 excess cases per 1,000 in high-elevation East Africa and southern Africa.
Research #Primary research #Other
Why it matters: It settles a decades-old debate on whether climate change has already raised malaria burden in African children.

Sep 6Sun

Sunday

07:08
CellPickScore6161
Structural basis for host membrane binding and remodeling by invading malaria parasites.
The endogenous structure of the Plasmodium falciparum moving junction, purified from invasion-stalled parasites, reveals a sailboat-shaped 1:1:1:1 complex of PfAMA1, PfRON2, PfRON4 and PfRON5. Two PfRON2 transmembrane helices anchor the complex in the red blood cell membrane, while PfRON2/4/5 form a basic platform that wedges seven amphipathic helices into the bilayer, indicating active host-membrane remodeling. Guided by the structure, a rationally designed small protein binder inhibits invasion.
Research #Primary research #Other
Why it matters: First native structure of the malaria moving junction enables structure-based design of an invasion inhibitor.

Aug 14Fri

Friday

21:30
CellPickScore7676
Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system.
DRT3 antiviral immunity depends on cooperation between class 1 and class 2 reverse transcriptase activities that together produce self-complementary double-stranded DNA. DRT3a copies a 5'-ACACAC-3' RNA template to make poly-(dTdG) repeats, while DRT3b makes poly-(dCdA) repeats without any nucleic acid template, using active-site-adjacent residues as nucleotide gates, as shown by cryo-electron microscopy. DRT3 is toxic in cells lacking RecBCD, and the phage-encoded RecBCD inhibitor Gam triggers abortive infection, defining how complementary DNA synthesis drives defense.
Research #Primary research #Other
Why it matters: It explains how two reverse transcriptases with distinct templating strategies cooperate to build antiviral double-stranded DNA.