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#生物标志物

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Oct 11Sun
  1. medicalxpress.com63

    Physical activity weakens link between genetic risk and depression severity, long-term data suggest

    Researchers at the University of Texas at San Antonio analyzed data from 23,517 adults in the NIH All of Us Research Program, combining depression polygenic risk scores, electronic health records and long-term Fitbit measurements averaging about 1.6 years per participant. Published in Nature Mental Health, the study found greater physical activity was associated with lower depression severity, with a stronger association among those with higher genetic vulnerability. The team aims to use such findings to develop personalized exercise recommendations for depression prevention and management.

    Why it matters: Long-term wearable data show physical activity buffers genetic risk of depression severity, informing precision-medicine approaches.

Oct 8Thu
  1. N Engl J Med40

    Advances in Systemic Treatment of Breast Cancer.

    A New England Journal of Medicine review traces systemic therapy for breast cancer since 2020, covering targeted therapies, antibody-drug conjugates and immunotherapy across biologic subtypes. CDK4/6 inhibitors remain foundational in hormone-receptor-positive, HER2-negative disease, trastuzumab deruxtecan is reshaping HER2-positive treatment, and immune checkpoint inhibitors have improved outcomes in triple-negative breast cancer. Unresolved issues include treatment sequencing, predictive biomarkers, circulating tumor DNA analysis and equitable access to high-cost therapies.

Oct 7Wed
  1. nature.com46

    Why sound, strong science alone isn’t enough in pandemic preparedness

    Polina Brangel, research-and-development data-innovation lead at the Coalition for Epidemic Preparedness Innovations (CEPI) in Oslo, is using AI to prepare for Disease X, the WHO term for a hypothetical pandemic pathogen. CEPI's programme works across the 25 known families of virus that infect humans, using simulations and AI to predict mutations and design vaccine candidates. She is also developing CEPI's Pandemic Preparedness Engine, a chatbot-like tool that would let researchers input a pathogen's genomic sequence and receive suggestions for vaccine antigens.

  2. jamanetwork.com51

    Defining Amyloid Positivity on the Centiloid Scale

    A JAMA piece examines how amyloid PET imaging defines amyloid positivity on the Centiloid scale in Alzheimer disease research and clinical care. Amyloid PET has shaped understanding of disease natural history, guided patient selection and served as a trial outcome measure, supporting FDA approval of amyloid-targeting therapies as the first disease-modifying class. Clinically it aids diagnosis in mild cognitive impairment and confirms plaques before treatment.

Sep 22Tue
  1. thelancet.com43

    [Correspondence] Multicancer detection tests: holy grail or cautionary tale?

    Grail's Galleri trial, which randomly assigned 140,000 UK residents to usual care plus multicancer detection testing or usual care alone, failed to meet its primary endpoint of reducing late-stage cancers. Results were presented at the ASCO scientific meeting in June 2026. The outcome sets back the aspirational goal of a single blood test able to identify most cancers.

    Why it matters: Negative result from the largest multicancer detection trial affects a leading screening programme.

Aug 18Tue
CBACBA Frontier Insights (CFI)Chinese Biopharmaceutical Association (CBA)www.cba-usa.org