#基因治疗/编辑

#基因治疗/编辑

Today 0 items

Sep 30Wed

Wednesday

18:42
nature.comPickScore7070
Intravenous hyaluronidase-expressing oncolytic adenovirus with chemotherapy in metastatic pancreatic cancer: a randomized phase 2b trial
Intravenous zabilugene almadenorepvec (VCN-01), a hyaluronidase-expressing oncolytic adenovirus, plus gemcitabine and nab-paclitaxel prolonged overall survival over chemotherapy alone in the randomized phase 2b VIRAGE trial in treatment-naive metastatic pancreatic cancer. The finding supports adding an oncolytic virus to standard first-line chemotherapy in this setting.
Clinical #Clinical readout #Oncology #Gene therapy & editing
Why it matters: First randomized evidence that an intravenous oncolytic adenovirus improves survival in metastatic pancreatic cancer.

Sep 8Tue

Tuesday

15:33
LancetPickScore7373
Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study.
A gene-edited porcine kidney (EGEN-2784) transplanted into a patient with end-stage kidney disease functioned immediately and maintained dialysis independence for 271 days before failing after immunosuppression reduction, with thrombotic microangiopathy despite negative donor-specific crossmatch. No porcine pathogen transmission or anti-HLA antibody change occurred. 82 days after nephrectomy, the patient received a human kidney allotransplant with immediate function and no sensitisation during 231 days of follow-up.
Clinical #Primary research #Gene therapy & editing #Rare disease
Why it matters: First living-recipient porcine kidney xenograft shows 271 days of dialysis independence and successful bridge to allotransplantation without sensitisation.